In early life she attended Penrhos College in Perth, Western Australia. She is best known for portraying Melissa Rafter (née Bannon) in the original cast of Packed to the Rafters. Her shock on-screen death was the highest rating episode of the hugely popular series, and gained her a nomination for the Silver Logie for Most Popular Actress in 2011. That same year, Ventoura starred alongside actor Daniel MacPherson in the Seven Network colonial drama Wild Boys.
In December 2014, Ventoura became engaged to longtime partner and Wild Boys co-star Daniel MacPherson, and they married in Noosa in November 2015.
Ventoura is also known for starring as Miki Mavros in the SBS television comedy series Kick, for which she earned two Logie nominations. She has also had a number of roles in the theatre, film and other television series such as drama series Last Man Standing, US feature films "Drive Hard", "Fatal Honeymoon" and the horror movie See No Evil. More recently, she appeared in Disney's Pirates of the Caribbean: Dead Men Tell No Tales, and The Osiris Child: Science Fiction Volume One by acclaimed Director Shane Abbess. In 2016 Zoe starred opposite Matt Nable as Sonya Hyde in the Australian thriller, "Hyde and Seek" for Channel 9.
