In addition to Late Night, Ruffin writes on the Comedy Central show Detroiters and is a regular narrator on another Comedy Central show, Drunk History. She is also a member of RobotDown, a Sketch comedy troupe, and a former performer at Boom Chicago, iO Theater, and The Second City. As of September 2016, she was working on a then-untitled single-camera comedy show as its co-executive Producer. In 2017, it was reported that NBC had put the show, entitled Going Dutch, in development, and that it would be based on Ruffin's life. The show will be co-written by Ruffin and Michael Starrbury. Also in 2017, she was nominated for, but did not win, a Writers Guild of America award in the category "Comedy/Variety (Including Talk) Series".
In February 2018 she hosted the 70th Writers Guild of America awards ceremony.
