Rossitto was born in Omaha, Nebraska and discovered by John Barrymore and made his screen debut opposite Barrymore in The Beloved Rogue (1927). That same year he appeared in Warner Brother's Old San Francisco. He appeared in the controversial 1932 film Freaks directed by Tod Browning, and another controversial film, 1938's Child Bride. During the 1940s, he appeared in several poverty row movies starring Bela Lugosi. He appeared frequently in television series and mini-series, particularly best known for the police drama Baretta, and his later film roles included appearances in Alex in Wonderland (1970), Brain of Blood (1971), Dracula vs. Frankenstein (1971), Little Cigars (1973), and Fairy Tales (1978). His last major role was as "Master" opposite Mel Gibson in Mad Max Beyond Thunderdome (1985).
Rossitto appeared alongside singer/songwriter Tom Waits and Lee Kolima on the cover art of Waits' 1983 album Swordfishtrombones, which paid homage to his performance in Freaks.
