Born in Washington, D.C., Sorkin began her career in cabaret in the late 1970s and early 1980s as a member of the comedy group The High-Heeled Women, alongside Mary Fulham, Tracey Berg, and Cassandra Danz.
From 1987 to 1989, Sorkin had the role of Geneva, a sexy maid to yuppie couple Richard and Linda Phillips, on the Fox dramedy series Duet. She would reprise this role on one episode of Open House, the sequel series to Duet. In 1990, she went on to be the original female co-host on America's Funniest People. She also wrote for Tiny Toon Adventures.
In 1992, Sorkin was dismissed from America's Funniest People by Vin Di Bona. In response, Sorkin filed a lawsuit against Di Bona, claiming she was dismissed from the show due to her race, after ABC Chairman Dan Burke had suggested to Di Bona that Sorkin be replaced by an African-American or a person of another ethnic minority. Sorkin sought $450,000 for lost earnings, and an additional unspecified amount for harm to her professional reputation and emotional injury. She additionally claimed that after she denounced the move as being racially motivated. Di Bona changed plans and hired new cohost Tawny Kitaen, who is also white.
Since 1995, Sorkin is married to television writer-producer Christopher Lloyd with whom she has two sons, Eli and Owen.
One of her more prominent roles was the wacky but lovable Calliope Jones, as seen on Days of Our Lives. She played this part from 1984 to 1990 and made return visits in 1992 and 2001. She reprised her role on the soap for the fourth time on February 24, 2006. She returned to Days for a limited run beginning on May 5, 2010.
She provided inspiration and does the voice of the animated character Harley Quinn, the Joker's sidekick and lover, created by Paul Dini, a college friend of Sorkin's who created Harley for the DC Comics TV series Batman: The Animated Series. Harley went on to appear in DC comic books and in further animated TV series including The New Batman Adventures, Static Shock, and Justice League, as well as Gotham Girls, an internet cartoon series. Sorkin has also voiced Harley in feature films and video games. Sorkin did not reprise her role in 2011's Batman: Arkham City and was succeeded by Tara Strong, one of her fellow DCAU voice actors.
