Mooney is best known for her role as Edna Harper on The WB drama series Everwood. The series aired from 2002-06. She has appeared in the many stage production and played roles of over 80 films and TV shows. Her notable film credits include Chapter Two opposite Marsha Mason, and Tootsie, Dead Poets Society and Domestic Disturbance.
On television she also starred of short-lived series Dream Street, Davis Rules and Kirk. Mooney guest-starred as the oblivious plutocrat Meg Wellman on Roseanne. She also appeared in Seinfeld, ER, Everybody Loves Raymond, Grey's Anatomy, Bones and Weeds. From 2012-13, she played the role of Supreme Court Justice Verna Thornton in the second season of ABC drama series Scandal created by Shonda Rhimes.
In 2014, she had a recurring role in the Netflix comedy series, Arrested Development. That same year, she joined the cast of The CW series, The Originals in a recurring role as Werewolf Matriarch.
In 2016, she was cast in the ABC drama pilot The Death of Eva Sofia Valdez, starring Gina Torres in a title role, with Eric Close, Melora Hardin, and Christina Pickles.
