Pflug graduated from Winter Park High School, Rollins College, and the University of Miami, receiving her BA in broadcasting and her minor in American history. She had a weekly radio show called The Magic Carpet, where she was the storyteller, and for four years hosted a weekly live interview talk show called Montage. Her background of interviewing led her to be the first woman to have a live weekly TV talk show in the late 1960s in Los Angeles, on KHJ-TV (channel 9).
Pflug's first major role was as U.S. Army nurse Lt. Maria "Dish" Schneider in the 1970 film MASH. Also in 1970, she starred in an episode of Marcus Welby, M.D. entitled "To Carry the Sun in a Golden Cup", where she played an ailing nurse. She also appeared in Catlow (1971) with Yul Brynner, and Where Does It Hurt? (1972) starring Peter Sellers. Her other notable roles include the voice of Invisible Girl in the 1967 animated version of Fantastic Four, Lt. Katherine O'Hara in the television series spin-off of Operation Petticoat, Boss Jack's wife in Traveller (1997), and Cynthia Vaughn in 1997's Midnight in the Garden of Good and Evil (her last role to date).
Pflug married Chuck Woolery in 1972. They had a daughter, Melissa. The couple divorced in 1980.
Pflug was the co-star of the made-for-television movie, The Night Strangler in 1973, which was a sequel to The Night Stalker of 1972, and a precursor of the TV series Kolchak: The Night Stalker of 1974–1975. She also starred in the TV werewolf movie Scream of the Wolf (1974) alongside Peter Graves and Clint Walker. Pflug was also a frequent panelist on the television game show Match Game from 1973 to 1981, a co-host with Allen Funt on the 1970s version of Candid Camera, and a regular in the TV series The Fall Guy in 1981–1982. In 1984, she was the first Actress to play Taylor Chapin in the syndicated soap opera Rituals.
