Wyatt graduated magna cum laude from St. Olaf College in Northfield, Minnesota, with a bachelor's degree in theatre (with a departmental distinction) and math. She has appeared in the films Legally Blonde (2001), Donnie Darko (2001), American Dreamz (2006) and Mr. Woodcock (2007). She had a supporting role in Southland Tales (2006), which premiered at the Cannes Film Festival in 2006. The film was directed by Richard Kelly, who previously directed Wyatt in Donnie Darko; the character, Terri Riley, a soccer mom who becomes a revolutionary, was written specifically for Wyatt.
Wyatt previously appeared in a recurring role in NBC's The Office as Lynn, the love interest of Kevin Malone. She first appeared in the episode "Blood Drive", where she meets Kevin at a singles party. Wyatt appeared in the supporting role "Rhonda Martin" in The Box, a horror movie released on November 6, 2009, starring Cameron Diaz, James Marsden and Frank Langella.
