Crow first appeared in a minor role on the U.S. soap opera Guiding Light in the 1980s, followed by a longer role as Beatrice McKechnie on As the World Turns. She later co-starred with Parker Stevenson in the short-lived science fiction TV series Probe. Since then, she has appeared in guest roles on various television shows, including Dark Angel, Everybody Loves Raymond, Touched by an Angel, Party of Five, Nip/Tuck, and The Mentalist. She had a major recurring role on Heroes as Sandra Bennet, wife of Primatech operative Noah Bennet (Jack Coleman).
Crow's first husband was actor Bill Shanks, who was a castmate on As the World Turns. They divorced in 1993. Crow is now married to fellow Heroes cast member Matthew John Armstrong, who played the role of Ted Sprague. She has one son.
