In 2012, Arfwedson starred in a television commercial for travel website Secret Escapes. Follow-up adverts were also released in 2013. She played Sheriff Angela Carter in Wrong Turn 5: Bloodlines, and in 2013, appeared in the second episode of BBC Three sitcom Way to Go, before joining the cast of BBC One medical drama Holby City.
In 2018, Arfwedson played the young Mrs Ayres in Lenny Abrahamson's film version of the novel The Little Stranger; the later life Mrs Ayres being played in the film by Charlotte Rampling.
