In 1991, Elsa Zylberstein appeared in Van Gogh directed by Maurice Pialat. In 1992, she won the Michel Simon Prize and the first of her three nominations for the César Award for Most Promising Actress. In 1993, she played a student in Beau fixe, and won the Prix Romy Schneider.
She inspired young Directors such as Pascale Bailly, Diane Bertrand and especially Martine Dugowson, who offered her the lead role alongside Romane Bohringer in Mina Tannenbaum (1994). She then appeared in Farinelli, Mr N., and Jefferson in Paris. She played Suzanne Valadon in Lautrec, and then the mistress of the Artist, Modigliani, in Modigliani. Zylberstein played a Yiddish singer who falls in love with a gay clarinetist in Man Is a Woman, with Antoine de Caunes. She also gained roles in Time Regained, Love Torn in a Dream, and That Day.
In 2006 she played Mathilde, an Orthodox Jewish woman faced with marriage problems in Little Jerusalem. She also appeared in J'invente rien, based on a novel by Christine Angot. In 2008, she was in two films presented at the Berlin Festival: I've Loved You So Long, with Kristin Scott Thomas, and La Fabrique des sentiments.
