In 1987, Meskimen married Tamra Shockley. They have a daughter named Taylor (born 1990). He is a Scientologist.
He voices Thom Cat, Neighbor John, and Stumpy in the Thom Cat short film on Random! Cartoons. Meskimen provided the voice of the Genie in the Aladdin franchise (which started with Disney Think Fast in 2008 and even before Robin Williams's death in 2014). In 2012, Meskimen voices several different characters in Lego The Lord of the Rings. As well, he is the voice of George W. Bush and other politicians for the Jib Jab animated shorts. In the same year, Meskimen voices and motion captures David Petraeus in Call of Duty: Black Ops 2.
Meskimen was a contestant on season eight of America's Got Talent. He has also toured various U.S. cities performing a one-man act, entitled "Jimpressions", of Celebrity impersonations and original characters. In 2018, Meskimen played George Washington in a popular GEICO commercial with a humorous take on "Washington Crossing the Delaware".
