Ghanimé grew up focusing on academics with the intent of becoming a Business man and going into real estate. He was not creative in high school and did not take drama classes or play a musical instrument. In his early twenties, Ghanimé began taking vocal lessons and hip-hop dance classes in order to explore his creative side. In 2004, Ghanimé had an uncredited, background role in Chasing Freedom starring Juliette Lewis. While on set, he became passionate for acting and knew he wanted to pursue it as a career.
After starting his career acting in commercials, Ghanimé was cast in his first guest-starring role as Graham in the CBC Television series Wild Roses. He then had small guest starring roles on Smallville and Supernatural in 2010 and The Secret Circle, Fairly Legal, and Arrow in 2012. Starting in 2012, Ghanimé had a recurring role as Dr. Jamie Albagetti on The CW series Emily Owens, M.D. and a starring role as Daniel Goose-Egg in the web series Soldiers of the Apocalypse, for which he also served as associate Producer. In 2013, he had supporting roles as Run in the Showcase miniseries Eve of Destruction and as the museum curator in the Hallmark Channel television movie The Hunters.
In 2015, Ghanimé was cast in the recurring role of Don Carlos in the third season of The CW series Reign. He also recurred as Justin Faysal on the Chiller horror anthology series Slasher in 2016.