After high school, Luke married at age 18. With a growing family to support, Luke went to work with his father in food trucks and other odd jobs. He was a state kickboxing champion in 1982-83.
In the early 1990s Luke, his father and his brother, Nicky, bought a property near the expressway in South Philadelphia. To avoid competition with other local businesses, the original Tony Luke's stand offered a more Diversified menu, offering hoagies and other fare, along with cheesesteaks. Luke Jr. soon took over the store's marketing.
He was the host of "Tony Luke's Eaglemania" which aired Saturday nights on Philadelphia's ABC affiliate WPVI-TV for a portion of the Eagles' 2010 season.
In 2011, after 31 years of marriage, Luke and his wife divorced. He has three sons, all of whom work for him.