He graduated from Columbia University with a bachelor's degree in 1988.
Maschio made guest appearances on various TV shows such as Bram & Alice, and he eventually landed the role of a hypersexual surgeon in Bill Lawrence's sitcom Scrubs, playing the recurring character of "Dr. Todd 'The Todd' Quinlan". Maschio also guest-starred in another Lawrence production, Spin City, in 1996, and played a jury member in Veronica Mars in 2005. Another role included the rapist Louis Browning on the daytime soap opera As the World Turns in 2006. In 2011, he appeared as Goldman in French comedy film "Hollywoo" with comidienne Florence Foresti.
