In the early part of her career, Valenza played the role of Dottie Thornton on All My Children from 1982 to 1986, earning a Daytime Emmy nomination for her work. She also showed up in a guest star appearance in the fifth season of The A-Team, and a recurring role as Lieutenant Winslow in Space: Above and Beyond. She also portrayed Jodie Abramovitz in Aaron Spelling's drama series The Heights. Valenza is best known to play female villains in video games such as Batman: Arkham Asylum and multiple Spider-Man games.
Valenza appeared in the 1988 Star Trek: The Next Generation episode "Coming of Age" as a Vulcan. She returned to Star Trek in 2017 with a voiceover role in the first two episodes of Star Trek: Discovery as the computer voice of the USS Shenzhou.
