He was born in Washington, D.C., the son of Madeline (née Cotter) and John Lewis Smith, Jr., who was a federal judge. He graduated from the Lawrenceville School in 1968. In 1972, he received his Bachelor of Arts degree in literature at Trinity College, Hartford, Connecticut.
He began his acting career in New York City in 1978, studying with Stella Adler and at the Actors Studio. His New York theater credits include the Broadway premiere productions of Next Fall, which was a 2010 Tony Award nominee for Best New Play, Wendy Wasserstein's An American Daughter) and Lanford Wilson's Burn This. He also co-starred with Judd Hirsch in the National Tour of the Tony Award-winning play Art. His numerous Off Broadway appearances include the Public Theater's Shakespeare in the Park production of "The Tempest' with Sam Waterston; Paula Vogel's Pulitzer Prize-winning How I Learned to Drive with Molly Ringwald; Charles Fuller's Pulitzer Prize-winning A Soldier's Play with Denzel Washington and Samuel L. Jackson; Michael Weller's Side Effects with Joely Richardson; Athol Fugard's The Blood Knot with Danny Glover; Horton Foote's The Old Friends with Betty Buckley; and the American Premiere of the Olivier Award-winning Cockfight Play, among many others. He was also a ten-year member of the Circle Repertory Company in New York working exclusively on the premiere productions of new American plays.
Smith has been nominated four times by the Los Angeles Drama Critics Circle, receiving the Outstanding Performance Award in 1996 for George M. Cohan's "The Tavern". He has received four Drama-Logue Awards and two Ovation Award nominations.
Smith has been married to Heidi Mueller Smith since 2001. He was previously married to Actress Mel Harris, with whom he has a daughter, Madeline, who is currently working on her PhD in History at the University of Chicago. He also has four stepchildren: Brianne, Christopher, Evan and Byron.
Smith is also an acting Teacher, for the past six years at The New School for Drama in New York, where he also served as the Department Head of the MFA Acting Program from 2015-2017. Prior to that he taught for several years at the Stella Adler Studio of Acting.
