His television work includes four BBC period dramas: The Moonstone with Keeley Hawes, The Buccaneers alongside Carla Gugino, Madame Bovary with Frances O'Connor, The Riff Raff Element in 1992 and 1993, and as Sir Charles Maulver in the 2007 five-part series Cranford. In 1999 he starred as Marshall in ITV's seven-part drama Wonderful You alongside his Future mother-in-law Phyllida Law and Future brother-in-law Richard Lumsden. Recently he filmed a number of readings of love scenes from a selection of classic and modern love scenes, from Thomas Hardy's Tess of the d'Urbervilles to Kiran Desai's The Inheritance of Loss for The Carte Noire Readers. In 2011, he appeared in Hallmark Channel's Honeymoon for One, starring Nicollette Sheridan.
He has been married to actor Emma Thompson since 2003.
He is also the Producer of the 2010 BBC/Masterpiece production The Song of Lunch starring his wife, Actress Emma Thompson, and Alan Rickman. Greg Wise made his theatrical return starring in Brad Fraser's Kill Me Now at Park Theatre in Finsbury Park, London from Thursday 19 February – Sunday 29 March 2015. In July 2015, Wise played the role of emotionally distanced father Gilbert Aldridge in the BBC's two-part television adaptation of Sadie Jones’ debut novel The Outcast.
