In 2005, he co-wrote the drama Dirty Filthy Love based upon his own experiences dealing with obsessive compulsive disorder. Dirty Filthy Love won a Royal Television Society Award for Best Single Drama and was nominated for the BAFTA Award for "Best Single Drama".
He has starred in long-running dramas such as Holby City, The Bill, Hollyoaks and Brookside. He has also made special appearances in; Hustle, Life on Mars, Dalziel and Pascoe, Silent Witness and Cape Wrath. In 2007, he starred in the Channel 4 docudrama, Richard Is My Boyfriend.
In 2009, Puleston-Davies was chosen to play the voiceover part of King Thistle in the children's animated television series Ben and Holly's Little Kingdom.
In 2010, Puleston-Davies joined Coronation Street as cast regular, Owen Armstrong. He quit the show in November 2014, and his on-screen character departed in April 2015.
In November 2014, ITV announced that Puleston-Davies had quit his role as Owen Armstrong in Coronation Street, and his character departed from the show on 15 April 2015.
