Lattanzi's feature film debut was in 1980 in the movie Xanadu.
Lattanzi's career consists mostly of small movie parts, though he did have a starring role in 1983's My Tutor. Other film credits include Rich and Famous, Grease 2, That's Life!, Roxanne, Catch Me If You Can, and Diving In. Lattanzi also had a significant role in the Australian soap opera, Paradise Beach, and he appeared in four of Newton-John's music videos: "Landslide", "Soul Kiss", "Toughen Up" and "Can't We Talk It Over In Bed".
While filming Xanadu, Lattanzi met Olivia Newton-John, whom he married in 1984. The couple has one daughter, Chloe Rose Lattanzi, born on January 17, 1986. By 1992, his acting career was largely over, and he took a job as a construction worker for a homebuilding company in California. Lattanzi and Newton-John moved to their farm in Australia in 1993 so that he could audition for the new soap opera, Paradise Beach. He won a six-month contract for the show.
In 2008, Lattanzi briefly appeared in the MTV reality series Rock the Cradle, supporting his daughter Chloe (a contestant on the show). That same year, Lattanzi—a lifelong environmentalist—was reported to be living off the grid near Malibu, California.
