LuPone's many off-Broadway performances include Twelfth Night (1980), Black Angel (1982), and Lennon (1982). He also has appeared in regional theater.
On television, LuPone appeared in five episodes of The Sopranos as Dr. Bruce Cusamano (1999–2007). He appeared on Law & Order: Criminal Intent for two episodes as Nelson Broome (2003–2009), and on Law & Order: Special Victims Unit for one episode in 2004. He also appeared on All My Children in the 1980s. He appears in the pilot episode of the NBC musical series Smash.
LuPone's Broadway performances include A Thousand Clowns (2001), True West (2000), A View from the Bridge (1997), Late Nite Comic (1987), St. Joan (1977), and The Magic Show (1974). For his performance as Zach in A Chorus Line (1976), he was nominated for the Tony Award for Best Featured Actor in a Musical. As artistic Director of MCC Theater in New York City, he produced Frozen (2004) and Reasons To Be Pretty (2008), both of which were nominated for the Tony Award for Best Play.
LuPone served as Director of the MFA Drama Program at The New School for Drama, New York City, until the spring of 2011.
