In 2016 he joined the cast of Penny Dreadful as the literary character Dr. Jekyll.
In 2017, Latif was cast as the role of Lieutenant Ash Tyler in Star Trek: Discovery, after initially being announced as playing a Klingon. It was later revealed that Latif had also portrayed the Klingon Voq in the series. In order to disguise this, the pseudonym Javid Iqbal was credited as portraying Voq. Latif chose this pseudonym to honor his deceased father.
Shazad Latif played ISIS fighter Bilel in the 2018 thriller film Profile by Timur Bekmambetov. The film takes place entirely on computer screens. It premiered at the 68th Berlin International Film Festival where it won the Panorama Audience Award.
