Serpico was born in Fort Sill in Lawton, Oklahoma. He was the youngest of three children. He became interested in acting after graduating from high school. He attended Boston University before transferring to and graduating from the State University of New York at Purchase in 1989. He has lived in Texas, Colorado, Germany, Georgia and Pennsylvania. He now lives in Charleston. He enjoys surfing and golf, and is an active Crossfitter.
Serpico began his career as a stunt performer. In 1997, he was cast in his first major acting role in Donnie Brasco. In television, Serpico has guest-starred on such shows as Law & Order, CSI: Miami, Law & Order: Criminal Intent, and Person of Interest.
