Bo began acting for film in 1939 in Ambición and made some 50 film appearances as an actor, but by the late 1940s he had already taken up an interest in film production and began as a Director, Producer, actor, and Screenwriter in the early 1950s. He was involved in almost 100 different films during his career.
Renowned filmmaker John Waters has claimed to be a big fan of Bó's filmography, and to have been influenced by it as well. Waters presented Bó's 1969 cult film Fuego as his annual selection within the 2002 Maryland Film Festival, and it was also a featured film in episode three of the Here! network original series John Waters Presents Movies That Will Corrupt You.
He was married to Teresa Machinandiarena, and had three children: María Inés, María Jesús, and Víctor. The erroneous popular belief is that he was married to Isabel Sarli. His son, Víctor Bo, was a prominent actor in Argentina during the 70s and 80s. His grandsons, Academy Award winners for Best Original Screenplay Nicolás Giacobone and Armando Bo Jr., credited as Armando Bo, are considered important Writers in their country, and have recently broken into Hollywood, collaborating as screenwriters on two films by Alejandro G. Iñárritu, Biutiful (2010) and Birdman (2014).