Butz's projects include the film Dan in Real Life (with Steve Carell, Juliette Binoche, and Dane Cook), released in October 2007, the world premiere of Is He Dead?, a hitherto unproduced Mark Twain play that opened at Broadway's Lyceum Theatre on December 9, 2007, and Fifty Words Off-Broadway with Elizebeth Marvel at the Lucille Lortel Theatre (2008). In January 2008, he appeared as Captain Richard King in the miniseries adaptation of the Lonesome Dove prequel, Comanche Moon.
Butz taught at Drew University, Madison, New Jersey for the spring semester in 2008 in the drama department.
Butz originated the role of Carl Hanratty in the musical Catch Me If You Can which played pre-Broadway tryouts at the 5th Avenue Theatre in Seattle, Washington from July 28 through August 14, 2009. Butz played the role of Carl Hanratty in the Broadway production of Catch Me if You Can, which opened on April 10, 2011 and closed in September 2011. For this role he won his second Drama Desk Award for Outstanding Actor in a Musical and his second Tony Award for Best Actor in a Musical.
From April to May 9, 2010, he returned to the Broadway stage in ENRON as Jeffrey Skilling. Despite Tony nominations, the play struggled with ticket sales.
Butz starred in the 2011 drama indie film Higher Ground with Vera Farmiga, who also directed it.
In 2012, he played Uncle Peck in a limited engagement revival of Paula Vogel's play How I Learned to Drive. He also starred in the 2013 film Better Living Through Chemistry. He played Kevin Rayburn in the 2015 Netflix television show Bloodline.
In 2013 he starred in the new Andrew Lippa musical Big Fish, which premiered in Chicago in the spring and opened on Broadway in the Neil Simon Theatre in October, directed by Susan Stroman.
